2q3y

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m (Protected "2q3y" [edit=sysop:move=sysop])
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[[Image:2q3y.png|left|200px]]
 
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{{STRUCTURE_2q3y| PDB=2q3y | SCENE= }}
{{STRUCTURE_2q3y| PDB=2q3y | SCENE= }}
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===Ancestral Corticiod Receptor in Complex with DOC===
===Ancestral Corticiod Receptor in Complex with DOC===
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{{ABSTRACT_PUBMED_17702911}}
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{{ABSTRACT_PUBMED_17702911}}
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==Disease==
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[[http://www.uniprot.org/uniprot/SHP_HUMAN SHP_HUMAN]] Defects in NR0B2 may be associated with obesity (OBESITY) [MIM:[http://omim.org/entry/601665 601665]]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:11136233</ref>
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==Function==
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[[http://www.uniprot.org/uniprot/SHP_HUMAN SHP_HUMAN]] Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.<ref>PMID:14752053</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:017702911</ref><references group="xtra"/>
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<ref group="xtra">PMID:017702911</ref><references group="xtra"/><references/>
[[Category: Unidentified]]
[[Category: Unidentified]]
[[Category: Bridgham, J T.]]
[[Category: Bridgham, J T.]]

Revision as of 16:24, 24 March 2013

Template:STRUCTURE 2q3y

Contents

Ancestral Corticiod Receptor in Complex with DOC

Template:ABSTRACT PUBMED 17702911

Disease

[SHP_HUMAN] Defects in NR0B2 may be associated with obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.[1]

Function

[SHP_HUMAN] Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.[2]

About this Structure

2q3y is a 2 chain structure with sequence from Unidentified. Full crystallographic information is available from OCA.

Reference

  • Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW. Crystal structure of an ancient protein: evolution by conformational epistasis. Science. 2007 Sep 14;317(5844):1544-8. Epub 2007 Aug 16. PMID:17702911
  1. ↑ Nishigori H, Tomura H, Tonooka N, Kanamori M, Yamada S, Sho K, Inoue I, Kikuchi N, Onigata K, Kojima I, Kohama T, Yamagata K, Yang Q, Matsuzawa Y, Miki T, Seino S, Kim MY, Choi HS, Lee YK, Moore DD, Takeda J. Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):575-80. Epub 2001 Jan 2. PMID:11136233 doi:10.1073/pnas.021544398
  2. ↑ Kim JY, Chu K, Kim HJ, Seong HA, Park KC, Sanyal S, Takeda J, Ha H, Shong M, Tsai MJ, Choi HS. Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. Mol Endocrinol. 2004 Apr;18(4):776-90. Epub 2004 Jan 29. PMID:14752053 doi:10.1210/me.2003-0311

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OCA

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