1buy
From Proteopedia
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{{STRUCTURE_1buy| PDB=1buy | SCENE= }} | {{STRUCTURE_1buy| PDB=1buy | SCENE= }} | ||
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===HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE=== | ===HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE=== | ||
| + | {{ABSTRACT_PUBMED_9783743}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/EPO_HUMAN EPO_HUMAN]] Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2) [MIM:[http://omim.org/entry/612623 612623]]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/EPO_HUMAN EPO_HUMAN]] Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:009783743</ref><references group="xtra"/> | + | <ref group="xtra">PMID:009783743</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Aoki, K H.]] | [[Category: Aoki, K H.]] | ||
Revision as of 16:25, 24 March 2013
Contents |
HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE
Template:ABSTRACT PUBMED 9783743
Disease
[EPO_HUMAN] Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2) [MIM:612623]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Function
[EPO_HUMAN] Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
About this Structure
1buy is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Cheetham JC, Smith DM, Aoki KH, Stevenson JL, Hoeffel TJ, Syed RS, Egrie J, Harvey TS. NMR structure of human erythropoietin and a comparison with its receptor bound conformation. Nat Struct Biol. 1998 Oct;5(10):861-6. PMID:9783743 doi:10.1038/2302
