3b29

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[[Image:3b29.png|left|200px]]
 
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{{STRUCTURE_3b29| PDB=3b29 | SCENE= }}
{{STRUCTURE_3b29| PDB=3b29 | SCENE= }}
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===Human leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside===
===Human leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside===
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{{ABSTRACT_PUBMED_22139193}}
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{{ABSTRACT_PUBMED_22139193}}
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==Disease==
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[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
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==Function==
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[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:022139193</ref><references group="xtra"/>
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<ref group="xtra">PMID:022139193</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ago, H.]]
[[Category: Ago, H.]]

Revision as of 16:59, 24 March 2013

Template:STRUCTURE 3b29

Contents

Human leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside

Template:ABSTRACT PUBMED 22139193

Disease

[LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.

Function

[LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.

About this Structure

3b29 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Saino H, Ago H, Ukita Y, Miyano M. Seleno-detergent MAD phasing of leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1666-73., Epub 2011 Nov 29. PMID:22139193 doi:10.1107/S1744309111042345

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OCA

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