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1xz9

From Proteopedia

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[[Image:1xz9.png|left|200px]]
 
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{{STRUCTURE_1xz9| PDB=1xz9 | SCENE= }}
{{STRUCTURE_1xz9| PDB=1xz9 | SCENE= }}
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===Structure of AF-6 PDZ domain===
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===Structure of AF-6 PDZ domain===
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==Disease==
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[[http://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.
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==Function==
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[[http://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:016671149</ref><references group="xtra"/>
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<ref group="xtra">PMID:016671149</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Boisguerin, P.]]
[[Category: Boisguerin, P.]]

Revision as of 17:30, 24 March 2013

Template:STRUCTURE 1xz9

Contents

Structure of AF-6 PDZ domain

Disease

[AFAD_HUMAN] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.

Function

[AFAD_HUMAN] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.

About this Structure

1xz9 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Joshi M, Vargas C, Boisguerin P, Diehl A, Krause G, Schmieder P, Moelling K, Hagen V, Schade M, Oschkinat H. Discovery of low-molecular-weight ligands for the AF6 PDZ domain. Angew Chem Int Ed Engl. 2006 Jun 2;45(23):3790-5. PMID:16671149 doi:10.1002/anie.200503965

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OCA

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