2ccs
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Novel piperazinyl, morpholino and piperidyl derivatives of the | + | Novel piperazinyl, morpholino and piperidyl derivatives of the pyrazole-based Hsp90 inhibitor CCT018159 are described. Structure-activity relationships have been elucidated by X-ray co-crystal analysis of the new compounds bound to the N-terminal domain of human Hsp90. Key features of the binding mode are essentially identical to the recently reported potent analogue VER-49009. The most potent of the new compounds has a methylsulfonylbenzyl substituent appended to the piperazine nitrogen, possesses an IC50 of less than 600 nM binding against the enzyme and demonstrates low micromolar inhibition of tumour cell proliferation. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Barril, X.]] | [[Category: Barril, X.]] | ||
| - | [[Category: Beswick, M | + | [[Category: Beswick, M C.]] |
[[Category: Collier, A.]] | [[Category: Collier, A.]] | ||
| - | [[Category: Drysdale, M | + | [[Category: Drysdale, M J.]] |
| - | [[Category: Dymock, B | + | [[Category: Dymock, B W.]] |
[[Category: Fink, A.]] | [[Category: Fink, A.]] | ||
[[Category: Grant, K.]] | [[Category: Grant, K.]] | ||
[[Category: Howes, R.]] | [[Category: Howes, R.]] | ||
| - | [[Category: Jordan, A | + | [[Category: Jordan, A M.]] |
[[Category: Massey, A.]] | [[Category: Massey, A.]] | ||
[[Category: Surgenor, A.]] | [[Category: Surgenor, A.]] | ||
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[[Category: pyrazole]] | [[Category: pyrazole]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:47:26 2008'' |
Revision as of 14:47, 21 February 2008
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HUMAN HSP90 WITH 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-3-YL)-BENZENE-1,2-DIOL
Overview
Novel piperazinyl, morpholino and piperidyl derivatives of the pyrazole-based Hsp90 inhibitor CCT018159 are described. Structure-activity relationships have been elucidated by X-ray co-crystal analysis of the new compounds bound to the N-terminal domain of human Hsp90. Key features of the binding mode are essentially identical to the recently reported potent analogue VER-49009. The most potent of the new compounds has a methylsulfonylbenzyl substituent appended to the piperazine nitrogen, possesses an IC50 of less than 600 nM binding against the enzyme and demonstrates low micromolar inhibition of tumour cell proliferation.
About this Structure
2CCS is a Single protein structure of sequence from Homo sapiens with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
4-Amino derivatives of the Hsp90 inhibitor CCT018159., Barril X, Beswick MC, Collier A, Drysdale MJ, Dymock BW, Fink A, Grant K, Howes R, Jordan AM, Massey A, Surgenor A, Wayne J, Workman P, Wright L, Bioorg Med Chem Lett. 2006 May 1;16(9):2543-8. Epub 2006 Feb 9. PMID:16480864
Page seeded by OCA on Thu Feb 21 16:47:26 2008
Categories: Homo sapiens | Single protein | Barril, X. | Beswick, M C. | Collier, A. | Drysdale, M J. | Dymock, B W. | Fink, A. | Grant, K. | Howes, R. | Jordan, A M. | Massey, A. | Surgenor, A. | Wayne, J. | Workman, P. | Wright, L. | 4BH | Atp-binding | Atpase | Chaperone | Heat shock | Hsp90 | Nucleotide-binding | Phosphorylation | Pyrazole
