1xyw

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[[Image:1xyw.png|left|200px]]
 
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{{STRUCTURE_1xyw| PDB=1xyw | SCENE= }}
{{STRUCTURE_1xyw| PDB=1xyw | SCENE= }}
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===elk prion protein===
===elk prion protein===
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{{ABSTRACT_PUBMED_15647363}}
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{{ABSTRACT_PUBMED_15647363}}
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==Disease==
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[[http://www.uniprot.org/uniprot/PRIO_CEREN PRIO_CEREN]] Note=PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
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==Function==
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[[http://www.uniprot.org/uniprot/PRIO_CEREN PRIO_CEREN]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:015647363</ref><references group="xtra"/>
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<ref group="xtra">PMID:015647363</ref><references group="xtra"/><references/>
[[Category: Cervus elaphus nelsoni]]
[[Category: Cervus elaphus nelsoni]]
[[Category: Bonjour, S.]]
[[Category: Bonjour, S.]]

Revision as of 18:35, 24 March 2013

Template:STRUCTURE 1xyw

Contents

elk prion protein

Template:ABSTRACT PUBMED 15647363

Disease

[PRIO_CEREN] Note=PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.

Function

[PRIO_CEREN] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

About this Structure

1xyw is a 1 chain structure with sequence from Cervus elaphus nelsoni. Full experimental information is available from OCA.

See Also

Reference

  • Gossert AD, Bonjour S, Lysek DA, Fiorito F, Wuthrich K. Prion protein NMR structures of elk and of mouse/elk hybrids. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):646-50. Epub 2005 Jan 12. PMID:15647363

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OCA

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