3plz
From Proteopedia
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{{STRUCTURE_3plz| PDB=3plz | SCENE= }} | {{STRUCTURE_3plz| PDB=3plz | SCENE= }} | ||
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===Human LRH1 LBD bound to GR470=== | ===Human LRH1 LBD bound to GR470=== | ||
+ | {{ABSTRACT_PUBMED_21391689}} | ||
+ | ==Disease== | ||
+ | [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. | ||
- | + | ==Function== | |
- | + | [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref> | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
- | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021391689</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Williams, S P.]] | [[Category: Williams, S P.]] | ||
[[Category: Xu, R.]] | [[Category: Xu, R.]] | ||
[[Category: Zuercher, W J.]] | [[Category: Zuercher, W J.]] | ||
+ | [[Category: Alpha helical sandwhich]] | ||
+ | [[Category: Co-activator]] | ||
+ | [[Category: Family five]] | ||
+ | [[Category: Nuclear receptor]] | ||
+ | [[Category: Transcription factor]] | ||
+ | [[Category: Transcription-receptor-agonist complex]] |
Revision as of 18:40, 24 March 2013
Contents |
Human LRH1 LBD bound to GR470
Template:ABSTRACT PUBMED 21391689
Disease
[NCOA2_HUMAN] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
Function
[NCOA2_HUMAN] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.[1]
About this Structure
3plz is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Whitby RJ, Stec J, Blind RD, Dixon S, Leesnitzer LM, Orband-Miller LA, Williams SP, Willson TM, Xu R, Zuercher WJ, Cai F, Ingraham HA. Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2). J Med Chem. 2011 Mar 10. PMID:21391689 doi:10.1021/jm1014296
- ↑ Voegel JJ, Heine MJ, Tini M, Vivat V, Chambon P, Gronemeyer H. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J. 1998 Jan 15;17(2):507-19. PMID:9430642 doi:10.1093/emboj/17.2.507