3plz

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[[Image:3plz.png|left|200px]]
 
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{{STRUCTURE_3plz| PDB=3plz | SCENE= }}
{{STRUCTURE_3plz| PDB=3plz | SCENE= }}
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===Human LRH1 LBD bound to GR470===
===Human LRH1 LBD bound to GR470===
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{{ABSTRACT_PUBMED_21391689}}
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==Disease==
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[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
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==Function==
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The line below this paragraph, {{ABSTRACT_PUBMED_21391689}}, adds the Publication Abstract to the page
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[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
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(as it appears on PubMed at http://www.pubmed.gov), where 21391689 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21391689}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:21391689</ref><references group="xtra"/>
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<ref group="xtra">PMID:021391689</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Williams, S P.]]
[[Category: Williams, S P.]]
[[Category: Xu, R.]]
[[Category: Xu, R.]]
[[Category: Zuercher, W J.]]
[[Category: Zuercher, W J.]]
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[[Category: Alpha helical sandwhich]]
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[[Category: Co-activator]]
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[[Category: Family five]]
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[[Category: Nuclear receptor]]
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[[Category: Transcription factor]]
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[[Category: Transcription-receptor-agonist complex]]

Revision as of 18:40, 24 March 2013

Template:STRUCTURE 3plz

Contents

Human LRH1 LBD bound to GR470

Template:ABSTRACT PUBMED 21391689

Disease

[NCOA2_HUMAN] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.

Function

[NCOA2_HUMAN] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.[1]

About this Structure

3plz is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Whitby RJ, Stec J, Blind RD, Dixon S, Leesnitzer LM, Orband-Miller LA, Williams SP, Willson TM, Xu R, Zuercher WJ, Cai F, Ingraham HA. Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2). J Med Chem. 2011 Mar 10. PMID:21391689 doi:10.1021/jm1014296
  1. Voegel JJ, Heine MJ, Tini M, Vivat V, Chambon P, Gronemeyer H. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J. 1998 Jan 15;17(2):507-19. PMID:9430642 doi:10.1093/emboj/17.2.507

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