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1d4v

From Proteopedia

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[[Image:1d4v.png|left|200px]]
 
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{{STRUCTURE_1d4v| PDB=1d4v | SCENE= }}
{{STRUCTURE_1d4v| PDB=1d4v | SCENE= }}
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===Crystal structure of trail-DR5 complex===
===Crystal structure of trail-DR5 complex===
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{{ABSTRACT_PUBMED_10542098}}
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{{ABSTRACT_PUBMED_10542098}}
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==Function==
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[[http://www.uniprot.org/uniprot/TNF10_HUMAN TNF10_HUMAN]] Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:010542098</ref><references group="xtra"/>
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<ref group="xtra">PMID:010542098</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Grimes, J M.]]
[[Category: Grimes, J M.]]

Revision as of 18:51, 24 March 2013

Template:STRUCTURE 1d4v

Contents

Crystal structure of trail-DR5 complex

Template:ABSTRACT PUBMED 10542098

Function

[TNF10_HUMAN] Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

About this Structure

1d4v is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Mongkolsapaya J, Grimes JM, Chen N, Xu XN, Stuart DI, Jones EY, Screaton GR. Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation. Nat Struct Biol. 1999 Nov;6(11):1048-53. PMID:10542098 doi:10.1038/14935

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