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3qb1
From Proteopedia
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{{STRUCTURE_3qb1| PDB=3qb1 | SCENE= }} | {{STRUCTURE_3qb1| PDB=3qb1 | SCENE= }} | ||
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===Interleukin-2 mutant D10=== | ===Interleukin-2 mutant D10=== | ||
| + | {{ABSTRACT_PUBMED_22446627}} | ||
| + | ==Disease== | ||
| + | [[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. | |
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| - | -- | + | |
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==About this Structure== | ==About this Structure== | ||
[[3qb1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QB1 OCA]. | [[3qb1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QB1 OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Interleukin|Interleukin]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:022446627</ref><references group="xtra"/> | + | <ref group="xtra">PMID:022446627</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bates, D L.]] | [[Category: Bates, D L.]] | ||
Revision as of 19:34, 24 March 2013
Contents |
Interleukin-2 mutant D10
Template:ABSTRACT PUBMED 22446627
Disease
[IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
Function
[IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
About this Structure
3qb1 is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC. Exploiting a natural conformational switch to engineer an interleukin-2 'superkine' Nature. 2012 Mar 25. doi: 10.1038/nature10975. PMID:22446627 doi:10.1038/nature10975
