2lke

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2lke.png|left|200px]]
 
- 
{{STRUCTURE_2lke| PDB=2lke | SCENE= }}
{{STRUCTURE_2lke| PDB=2lke | SCENE= }}
- 
===Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails===
===Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails===
 +
{{ABSTRACT_PUBMED_22052909}}
-
{{ABSTRACT_PUBMED_22052909}}
+
==Disease==
 +
[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[http://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
 +
 
 +
==Function==
 +
[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
==About this Structure==
==About this Structure==
Line 14: Line 16:
==Reference==
==Reference==
-
<ref group="xtra">PMID:022052909</ref><references group="xtra"/>
+
<ref group="xtra">PMID:022052909</ref><references group="xtra"/><references/>
[[Category: Amalraj, M.]]
[[Category: Amalraj, M.]]
[[Category: Bhattacharjya, S.]]
[[Category: Bhattacharjya, S.]]

Revision as of 19:41, 24 March 2013

Template:STRUCTURE 2lke

Contents

Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails

Template:ABSTRACT PUBMED 22052909

Disease

[ITAM_HUMAN] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.

Function

[ITAM_HUMAN] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

About this Structure

2lke is a 1 chain structure. Full experimental information is available from OCA.

See Also

Reference

  • Chua GL, Tang XY, Amalraj M, Tan SM, Bhattacharjya S. Structures and interaction analyses of the integrin alphaMbeta2 cytoplasmic tails. J Biol Chem. 2011 Nov 3. PMID:22052909 doi:10.1074/jbc.M111.280164

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2lke"
Personal tools