3ix0
From Proteopedia
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{{STRUCTURE_3ix0| PDB=3ix0 | SCENE= }} | {{STRUCTURE_3ix0| PDB=3ix0 | SCENE= }} | ||
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===Crystal structure of human seminal plasma protein PSP94=== | ===Crystal structure of human seminal plasma protein PSP94=== | ||
| + | {{ABSTRACT_PUBMED_20184897}} | ||
| - | + | ==Disease== | |
| - | + | [[http://www.uniprot.org/uniprot/MSMB_HUMAN MSMB_HUMAN]] Defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13 (HPC13) [MIM:[http://omim.org/entry/611928 611928]]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020184897</ref><ref group="xtra">PMID:019342788</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Jagtap, D D.]] | [[Category: Jagtap, D D.]] | ||
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[[Category: Kumar, M.]] | [[Category: Kumar, M.]] | ||
[[Category: Mahale, S D.]] | [[Category: Mahale, S D.]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Antitumor protein]] | [[Category: Antitumor protein]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
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[[Category: Disulfide bond]] | [[Category: Disulfide bond]] | ||
[[Category: Greek key motif]] | [[Category: Greek key motif]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
Revision as of 20:35, 24 March 2013
Contents |
Crystal structure of human seminal plasma protein PSP94
Template:ABSTRACT PUBMED 20184897
Disease
[MSMB_HUMAN] Defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13 (HPC13) [MIM:611928]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
About this Structure
3ix0 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kumar A, Jagtap DD, Mahale SD, Kumar M. Crystal structure of prostate secretory protein PSP94 shows an edge-to-edge association of two monomers to form a homodimer. J Mol Biol. 2010 Apr 9;397(4):947-56. Epub 2010 Feb 23. PMID:20184897 doi:10.1016/j.jmb.2010.02.035
- Kumar M, Jagtap DD, Mahale SD, Prashar V, Kumar A, Das A, Bihani SC, Ferrer JL, Hosur MV, Ramanadham M. Crystallization and preliminary X-ray diffraction analysis of human seminal plasma protein PSP94. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Apr 1;65(Pt, 4):389-91. Epub 2009 Mar 25. PMID:19342788 doi:10.1107/S1744309109008549
