3ose
From Proteopedia
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{{STRUCTURE_3ose| PDB=3ose | SCENE= }} | {{STRUCTURE_3ose| PDB=3ose | SCENE= }} | ||
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===Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase=== | ===Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase=== | ||
| + | {{ABSTRACT_PUBMED_21145462}} | ||
| + | ==Disease== | ||
| + | [[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites. | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).<ref>PMID:11433294</ref><ref>PMID:17573348</ref> | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021145462</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Lemmon, M A.]] | [[Category: Lemmon, M A.]] | ||
[[Category: Moravcevic, K.]] | [[Category: Moravcevic, K.]] | ||
| + | [[Category: Kinase]] | ||
| + | [[Category: Lipid binding protein]] | ||
| + | [[Category: Membrane association]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 21:25, 24 March 2013
Contents |
Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase
Template:ABSTRACT PUBMED 21145462
Disease
[MARK1_HUMAN] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.
Function
[MARK1_HUMAN] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).[1][2]
About this Structure
3ose is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Moravcevic K, Mendrola JM, Schmitz KR, Wang YH, Slochower D, Janmey PA, Lemmon MA. Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. Cell. 2010 Dec 10;143(6):966-77. PMID:21145462 doi:10.1016/j.cell.2010.11.028
- ↑ Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nat Cell Biol. 2001 Jul;3(7):628-36. PMID:11433294 doi:10.1038/35083016
- ↑ Kojima Y, Miyoshi H, Clevers HC, Oshima M, Aoki M, Taketo MM. Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling. J Biol Chem. 2007 Aug 10;282(32):23532-40. Epub 2007 Jun 15. PMID:17573348 doi:10.1074/jbc.M700590200
