3g6d

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[[Image:3g6d.png|left|200px]]
 
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{{STRUCTURE_3g6d| PDB=3g6d | SCENE= }}
{{STRUCTURE_3g6d| PDB=3g6d | SCENE= }}
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===Crystal structure of the complex between CNTO607 Fab and IL-13===
===Crystal structure of the complex between CNTO607 Fab and IL-13===
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{{ABSTRACT_PUBMED_19361524}}
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{{ABSTRACT_PUBMED_19361524}}
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==Disease==
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[[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[http://omim.org/entry/607154 607154]]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.
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==Function==
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[[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019361524</ref><references group="xtra"/>
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<ref group="xtra">PMID:019361524</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Gilliland, G L.]]
[[Category: Gilliland, G L.]]

Revision as of 21:50, 24 March 2013

Template:STRUCTURE 3g6d

Contents

Crystal structure of the complex between CNTO607 Fab and IL-13

Template:ABSTRACT PUBMED 19361524

Disease

[IL13_HUMAN] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.

Function

[IL13_HUMAN] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

About this Structure

3g6d is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Teplyakov A, Obmolova G, Wu SJ, Luo J, Kang J, O'Neil K, Gilliland GL. Epitope mapping of anti-interleukin-13 neutralizing antibody CNTO607. J Mol Biol. 2009 May 29;389(1):115-23. Epub 2009 Apr 8. PMID:19361524 doi:10.1016/j.jmb.2009.03.076

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OCA

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