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2idx

From Proteopedia

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[[Image:2idx.png|left|200px]]
 
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{{STRUCTURE_2idx| PDB=2idx | SCENE= }}
{{STRUCTURE_2idx| PDB=2idx | SCENE= }}
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===Structure of Human ATP:Cobalamin adenosyltransferase bound to ATP.===
===Structure of Human ATP:Cobalamin adenosyltransferase bound to ATP.===
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{{ABSTRACT_PUBMED_17176040}}
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{{ABSTRACT_PUBMED_17176040}}
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==Disease==
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[[http://www.uniprot.org/uniprot/MMAB_HUMAN MMAB_HUMAN]] Defects in MMAB are the cause of methylmalonic aciduria type cblB (MMAB) [MIM:[http://omim.org/entry/251110 251110]]; also known as methylmalonic aciduria type B or vitamin B12-responsive methylmalonicaciduria of cblB complementation type. MMAB is a disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive.<ref>PMID:12471062</ref><ref>PMID:12514191</ref><ref>PMID:15781192</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:017176040</ref><references group="xtra"/>
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<ref group="xtra">PMID:017176040</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hill, C P.]]
[[Category: Hill, C P.]]

Revision as of 21:54, 24 March 2013

Template:STRUCTURE 2idx

Contents

Structure of Human ATP:Cobalamin adenosyltransferase bound to ATP.

Template:ABSTRACT PUBMED 17176040

Disease

[MMAB_HUMAN] Defects in MMAB are the cause of methylmalonic aciduria type cblB (MMAB) [MIM:251110]; also known as methylmalonic aciduria type B or vitamin B12-responsive methylmalonicaciduria of cblB complementation type. MMAB is a disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive.[1][2][3]

About this Structure

2idx is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Dobson CM, Wai T, Leclerc D, Kadir H, Narang M, Lerner-Ellis JP, Hudson TJ, Rosenblatt DS, Gravel RA. Identification of the gene responsible for the cblB complementation group of vitamin B12-dependent methylmalonic aciduria. Hum Mol Genet. 2002 Dec 15;11(26):3361-9. PMID:12471062
  2. ↑ Leal NA, Park SD, Kima PE, Bobik TA. Identification of the human and bovine ATP:Cob(I)alamin adenosyltransferase cDNAs based on complementation of a bacterial mutant. J Biol Chem. 2003 Mar 14;278(11):9227-34. Epub 2003 Jan 3. PMID:12514191 doi:10.1074/jbc.M212739200
  3. ↑ Martinez MA, Rincon A, Desviat LR, Merinero B, Ugarte M, Perez B. Genetic analysis of three genes causing isolated methylmalonic acidemia: identification of 21 novel allelic variants. Mol Genet Metab. 2005 Apr;84(4):317-25. Epub 2005 Jan 22. PMID:15781192 doi:S1096-7192(04)00307-5

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OCA

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