3bn9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3bn9.png|left|200px]]
 
- 
{{STRUCTURE_3bn9| PDB=3bn9 | SCENE= }}
{{STRUCTURE_3bn9| PDB=3bn9 | SCENE= }}
- 
===Crystal Structure of MT-SP1 in complex with Fab Inhibitor E2===
===Crystal Structure of MT-SP1 in complex with Fab Inhibitor E2===
 +
{{ABSTRACT_PUBMED_18514224}}
-
{{ABSTRACT_PUBMED_18514224}}
+
==Disease==
 +
[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[http://omim.org/entry/610765 610765]]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref>
 +
 
 +
==Function==
 +
[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
==About this Structure==
==About this Structure==
Line 14: Line 16:
==Reference==
==Reference==
-
<ref group="xtra">PMID:018514224</ref><references group="xtra"/>
+
<ref group="xtra">PMID:018514224</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Matriptase]]
[[Category: Matriptase]]

Revision as of 21:56, 24 March 2013

Template:STRUCTURE 3bn9

Contents

Crystal Structure of MT-SP1 in complex with Fab Inhibitor E2

Template:ABSTRACT PUBMED 18514224

Disease

[ST14_HUMAN] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.[1]

Function

[ST14_HUMAN] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.

About this Structure

3bn9 is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Farady CJ, Egea PF, Schneider EL, Darragh MR, Craik CS. Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition. J Mol Biol. 2008 Jul 4;380(2):351-60. Epub 2008 May 11. PMID:18514224 doi:10.1016/j.jmb.2008.05.009
  1. ↑ Basel-Vanagaite L, Attia R, Ishida-Yamamoto A, Rainshtein L, Ben Amitai D, Lurie R, Pasmanik-Chor M, Indelman M, Zvulunov A, Saban S, Magal N, Sprecher E, Shohat M. Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase. Am J Hum Genet. 2007 Mar;80(3):467-77. Epub 2007 Jan 23. PMID:17273967 doi:S0002-9297(07)60095-0

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bn9"
Personal tools