2jom

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[[Image:2jom.png|left|200px]]
 
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{{STRUCTURE_2jom| PDB=2jom | SCENE= }}
{{STRUCTURE_2jom| PDB=2jom | SCENE= }}
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===NMR structure of rabbit prion protein mutation I214V===
===NMR structure of rabbit prion protein mutation I214V===
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{{ABSTRACT_PUBMED_20949107}}
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{{ABSTRACT_PUBMED_20949107}}
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==Disease==
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[[http://www.uniprot.org/uniprot/PRIO_RABIT PRIO_RABIT]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
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==Function==
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[[http://www.uniprot.org/uniprot/PRIO_RABIT PRIO_RABIT]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:020949107</ref><references group="xtra"/>
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<ref group="xtra">PMID:020949107</ref><references group="xtra"/><references/>
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Li, J.]]
[[Category: Li, J.]]

Revision as of 21:56, 24 March 2013

Template:STRUCTURE 2jom

Contents

NMR structure of rabbit prion protein mutation I214V

Template:ABSTRACT PUBMED 20949107

Disease

[PRIO_RABIT] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.

Function

[PRIO_RABIT] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

About this Structure

2jom is a 1 chain structure with sequence from Oryctolagus cuniculus. Full experimental information is available from OCA.

See Also

Reference

  • Wen Y, Li J, Xiong M, Peng Y, Yao W, Hong J, Lin D. Solution structure and dynamics of the I214V mutant of the rabbit prion protein. PLoS One. 2010 Oct 7;5(10):e13273. PMID:20949107 doi:10.1371/journal.pone.0013273

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OCA

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