3s91
From Proteopedia
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{{STRUCTURE_3s91| PDB=3s91 | SCENE= }} | {{STRUCTURE_3s91| PDB=3s91 | SCENE= }} | ||
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===Crystal Structure of the first bromodomain of human BRD3 in complex with the inhibitor JQ1=== | ===Crystal Structure of the first bromodomain of human BRD3 in complex with the inhibitor JQ1=== | ||
| + | ==Disease== | ||
| + | [[http://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN]] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein. | ||
| + | |||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN]] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3s91]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S91 OCA]. | [[3s91]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S91 OCA]. | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
Revision as of 22:06, 24 March 2013
Contents |
Crystal Structure of the first bromodomain of human BRD3 in complex with the inhibitor JQ1
Disease
[BRD3_HUMAN] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.
Function
[BRD3_HUMAN] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.[1]
About this Structure
3s91 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ LeRoy G, Rickards B, Flint SJ. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell. 2008 Apr 11;30(1):51-60. doi: 10.1016/j.molcel.2008.01.018. PMID:18406326 doi:10.1016/j.molcel.2008.01.018
Categories: Homo sapiens | Arrowsmith, C H. | Bountra, C. | Bradner, J E. | Delft, F von. | Edwards, A M. | Fedorov, O. | Felletar, I. | Filippakopoulos, P. | Keates, T. | Knapp, S. | Muniz, J. | Picaud, S. | Qi, J. | SGC, Structural Genomics Consortium. | Weigelt, J. | Brd3 | Bromodomain containing protein 3 | Jq1 | Orfx | Ring3 like gene | Ring3l | Sgc | Structural genomic | Structural genomics consortium | Unknown function
