1oe7
From Proteopedia
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[[Category: vaccine candidate]] | [[Category: vaccine candidate]] | ||
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Revision as of 13:46, 30 October 2007
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28KDA GLUTATHIONE S-TRANSFERASE FROM SCHISTOSOMA HAEMATOBIUM
Overview
Schistomiasis is a debilitating parasitic disease which affects 200, million people, causing life-threatening complications in 10% of the, patients. This paper reports the crystal structure of the Schistosoma, haematobium 28 kDa glutathione S-transferase, a multifunctional enzyme, involved in host-parasite interactions and presently considered as a, promising vaccine candidate against schistosomiasis. The structures of the, GSH-free enzyme, as well as the partially (approximately 40%) and almost, fully (approximately 80%) GSH-saturated enzyme, exhibit a unique feature, absent in previous GST structures, concerning the crucial and invariant, Tyr10 side chain which occupies two alternative positions. The canonical, conformer, which allows an H-bond to be formed between the side chain, ... [(full description)]
About this Structure
1OE7 is a [Single protein] structure of sequence from [Schistosoma haematobium] with GSH as [ligand]. Active as [Glutathione transferase], with EC number [2.5.1.18]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the 28 kDa glutathione S-transferase from Schistosoma haematobium., Johnson KA, Angelucci F, Bellelli A, Herve M, Fontaine J, Tsernoglou D, Capron A, Trottein F, Brunori M, Biochemistry. 2003 Sep 2;42(34):10084-94. PMID:12939136
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