1zgy

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[[Image:1zgy.png|left|200px]]
 
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{{STRUCTURE_1zgy| PDB=1zgy | SCENE= }}
{{STRUCTURE_1zgy| PDB=1zgy | SCENE= }}
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===Structural and Biochemical Basis for Selective Repression of the Orphan Nuclear Receptor LRH-1 by SHP===
===Structural and Biochemical Basis for Selective Repression of the Orphan Nuclear Receptor LRH-1 by SHP===
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{{ABSTRACT_PUBMED_15976031}}
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{{ABSTRACT_PUBMED_15976031}}
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==Function==
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[[http://www.uniprot.org/uniprot/NR0B2_RAT NR0B2_RAT]] Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:015976031</ref><references group="xtra"/>
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<ref group="xtra">PMID:015976031</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]

Revision as of 22:58, 24 March 2013

Template:STRUCTURE 1zgy

Contents

Structural and Biochemical Basis for Selective Repression of the Orphan Nuclear Receptor LRH-1 by SHP

Template:ABSTRACT PUBMED 15976031

Function

[NR0B2_RAT] Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.

About this Structure

1zgy is a 2 chain structure with sequence from Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA.

See Also

Reference

  • Li Y, Choi M, Suino K, Kovach A, Daugherty J, Kliewer SA, Xu HE. Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner. Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9505-10. Epub 2005 Jun 23. PMID:15976031

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OCA

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