1dfp
From Proteopedia
(Difference between revisions)
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| - | [[Image:1dfp.png|left|200px]] | ||
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{{STRUCTURE_1dfp| PDB=1dfp | SCENE= }} | {{STRUCTURE_1dfp| PDB=1dfp | SCENE= }} | ||
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===FACTOR D INHIBITED BY DIISOPROPYL FLUOROPHOSPHATE=== | ===FACTOR D INHIBITED BY DIISOPROPYL FLUOROPHOSPHATE=== | ||
| + | {{ABSTRACT_PUBMED_15299948}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN]] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:[http://omim.org/entry/613912 613912]]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN]] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:015299948</ref><references group="xtra"/> | + | <ref group="xtra">PMID:015299948</ref><references group="xtra"/><references/> |
[[Category: Complement factor D]] | [[Category: Complement factor D]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 23:00, 24 March 2013
Contents |
FACTOR D INHIBITED BY DIISOPROPYL FLUOROPHOSPHATE
Template:ABSTRACT PUBMED 15299948
Disease
[CFAD_HUMAN] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:613912]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.
Function
[CFAD_HUMAN] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
About this Structure
1dfp is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Cole LB, Chu N, Kilpatrick JM, Volanakis JE, Narayana SV, Babu YS. Structure of diisopropyl fluorophosphate-inhibited factor D. Acta Crystallogr D Biol Crystallogr. 1997 Mar 1;53(Pt 2):143-50. PMID:15299948 doi:10.1107/S0907444996012991
