2ios

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[[Image:2ios.png|left|200px]]
 
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{{STRUCTURE_2ios| PDB=2ios | SCENE= }}
{{STRUCTURE_2ios| PDB=2ios | SCENE= }}
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===Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form 3===
===Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form 3===
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{{ABSTRACT_PUBMED_17060447}}
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{{ABSTRACT_PUBMED_17060447}}
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==Disease==
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[[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Note=Decreases benign tumor development and malignant progression.
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==Function==
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[[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.<ref>PMID:12482958</ref><ref>PMID:12894233</ref><ref>PMID:16024603</ref><ref>PMID:17060447</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:017060447</ref><references group="xtra"/>
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<ref group="xtra">PMID:017060447</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: LaRonde-LeBlanc, N A.]]
[[Category: LaRonde-LeBlanc, N A.]]

Revision as of 23:15, 24 March 2013

Template:STRUCTURE 2ios

Contents

Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form 3

Template:ABSTRACT PUBMED 17060447

Disease

[PDCD4_MOUSE] Note=Decreases benign tumor development and malignant progression.

Function

[PDCD4_MOUSE] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.[1][2][3][4]

About this Structure

2ios is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

See Also

Reference

  • LaRonde-LeBlanc N, Santhanam AN, Baker AR, Wlodawer A, Colburn NH. Structural basis for inhibition of translation by the tumor suppressor Pdcd4. Mol Cell Biol. 2007 Jan;27(1):147-56. Epub 2006 Oct 23. PMID:17060447 doi:10.1128/MCB.00867-06
  1. ↑ Yang HS, Jansen AP, Komar AA, Zheng X, Merrick WC, Costes S, Lockett SJ, Sonenberg N, Colburn NH. The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol Cell Biol. 2003 Jan;23(1):26-37. PMID:12482958
  2. ↑ Bohm M, Sawicka K, Siebrasse JP, Brehmer-Fastnacht A, Peters R, Klempnauer KH. The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA. Oncogene. 2003 Jul 31;22(31):4905-10. PMID:12894233 doi:10.1038/sj.onc.1206710
  3. ↑ Jansen AP, Camalier CE, Colburn NH. Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. Cancer Res. 2005 Jul 15;65(14):6034-41. PMID:16024603 doi:65/14/6034
  4. ↑ LaRonde-LeBlanc N, Santhanam AN, Baker AR, Wlodawer A, Colburn NH. Structural basis for inhibition of translation by the tumor suppressor Pdcd4. Mol Cell Biol. 2007 Jan;27(1):147-56. Epub 2006 Oct 23. PMID:17060447 doi:10.1128/MCB.00867-06

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