2lkj
From Proteopedia
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{{STRUCTURE_2lkj| PDB=2lkj | SCENE= }} | {{STRUCTURE_2lkj| PDB=2lkj | SCENE= }} | ||
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===Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails=== | ===Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails=== | ||
| + | {{ABSTRACT_PUBMED_22052909}} | ||
| + | ==Disease== | ||
| + | [[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[http://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:022052909</ref><references group="xtra"/> | + | <ref group="xtra">PMID:022052909</ref><references group="xtra"/><references/> |
[[Category: Amalraj, M.]] | [[Category: Amalraj, M.]] | ||
[[Category: Bhattacharjya, S.]] | [[Category: Bhattacharjya, S.]] | ||
Revision as of 23:35, 24 March 2013
Contents |
Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails
Template:ABSTRACT PUBMED 22052909
Disease
[ITAM_HUMAN] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Function
[ITAM_HUMAN] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
About this Structure
2lkj is a 1 chain structure. Full experimental information is available from OCA.
Reference
- Chua GL, Tang XY, Amalraj M, Tan SM, Bhattacharjya S. Structures and interaction analyses of the integrin alphaMbeta2 cytoplasmic tails. J Biol Chem. 2011 Nov 3. PMID:22052909 doi:10.1074/jbc.M111.280164
