3e9k

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m (Protected "3e9k" [edit=sysop:move=sysop])
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[[Image:3e9k.png|left|200px]]
 
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{{STRUCTURE_3e9k| PDB=3e9k | SCENE= }}
{{STRUCTURE_3e9k| PDB=3e9k | SCENE= }}
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===Crystal structure of Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex===
===Crystal structure of Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex===
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{{ABSTRACT_PUBMED_19143568}}
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{{ABSTRACT_PUBMED_19143568}}
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==Disease==
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[[http://www.uniprot.org/uniprot/KYNU_HUMAN KYNU_HUMAN]] Note=Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively.[HAMAP-Rule:MF_03017]
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==Function==
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[[http://www.uniprot.org/uniprot/KYNU_HUMAN KYNU_HUMAN]] Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.[HAMAP-Rule:MF_03017]
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019143568</ref><references group="xtra"/>
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<ref group="xtra">PMID:019143568</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kynureninase]]
[[Category: Kynureninase]]

Revision as of 00:27, 25 March 2013

Template:STRUCTURE 3e9k

Contents

Crystal structure of Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex

Template:ABSTRACT PUBMED 19143568

Disease

[KYNU_HUMAN] Note=Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively.[HAMAP-Rule:MF_03017]

Function

[KYNU_HUMAN] Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.[HAMAP-Rule:MF_03017]

About this Structure

3e9k is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Lima S, Kumar S, Gawandi V, Momany C, Phillips RS. Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity. J Med Chem. 2009 Jan 22;52(2):389-96. PMID:19143568 doi:10.1021/jm8010806

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