2bb5
From Proteopedia
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{{STRUCTURE_2bb5| PDB=2bb5 | SCENE= }} | {{STRUCTURE_2bb5| PDB=2bb5 | SCENE= }} | ||
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===Structure of Human Transcobalamin in complex with Cobalamin=== | ===Structure of Human Transcobalamin in complex with Cobalamin=== | ||
| + | {{ABSTRACT_PUBMED_16537422}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:[http://omim.org/entry/275350 275350]]. This results in various forms of anemia. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:016537422</ref><references group="xtra"/> | + | <ref group="xtra">PMID:016537422</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Fedosov, S N.]] | [[Category: Fedosov, S N.]] | ||
Revision as of 00:44, 25 March 2013
Contents |
Structure of Human Transcobalamin in complex with Cobalamin
Template:ABSTRACT PUBMED 16537422
Disease
[TCO2_HUMAN] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]. This results in various forms of anemia.
Function
[TCO2_HUMAN] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
About this Structure
2bb5 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Wuerges J, Garau G, Geremia S, Fedosov SN, Petersen TE, Randaccio L. Structural basis for mammalian vitamin B12 transport by transcobalamin. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4386-91. Epub 2006 Mar 14. PMID:16537422
