2ctn
From Proteopedia
(New page: 200px<br /><applet load="2ctn" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ctn" /> '''STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPO...) |
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| - | [[Image:2ctn.jpg|left|200px]]<br /><applet load="2ctn" size=" | + | [[Image:2ctn.jpg|left|200px]]<br /><applet load="2ctn" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2ctn" /> | caption="2ctn" /> | ||
'''STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES'''<br /> | '''STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The regulation of cardiac muscle contraction must differ from that of | + | The regulation of cardiac muscle contraction must differ from that of skeletal muscles to effect different physiological and contractile properties. Cardiac troponin C (TnC), the key regulator of cardiac muscle contraction, possesses different functional and Ca2+-binding properties compared with skeletal TnC and features a Ca2+-binding site I, which is naturally inactive. The structure of cardiac TnC in the Ca2+-saturated state has been determined by nuclear magnetic resonance spectroscopy. The regulatory domain exists in a "closed" conformation even in the Ca2+-bound (the "on") state, in contrast to all predicted models and differing significantly from the calcium-induced structure observed in skeletal TnC. This structure in the Ca2+-bound state, and its subsequent interaction with troponin I (TnI), are crucial in determining the specific regulatory mechanism for cardiac muscle contraction. Further, it will allow for an understanding of the action of calcium-sensitizing drugs, which bind to cardiac TnC and are known to enhance the ability of cardiac TnC to activate cardiac muscle contraction. |
==About this Structure== | ==About this Structure== | ||
| - | 2CTN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2CTN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Gagne, S | + | [[Category: Gagne, S M.]] |
| - | [[Category: Li, M | + | [[Category: Li, M X.]] |
[[Category: Liu, W.]] | [[Category: Liu, W.]] | ||
| - | [[Category: Putkey, J | + | [[Category: Putkey, J A.]] |
| - | [[Category: Sia, S | + | [[Category: Sia, S K.]] |
[[Category: Spyracopoulos, L.]] | [[Category: Spyracopoulos, L.]] | ||
| - | [[Category: Sykes, B | + | [[Category: Sykes, B D.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: calcium-binding protein]] | [[Category: calcium-binding protein]] | ||
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[[Category: regulatory]] | [[Category: regulatory]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:52:28 2008'' |
Revision as of 14:52, 21 February 2008
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STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES
Overview
The regulation of cardiac muscle contraction must differ from that of skeletal muscles to effect different physiological and contractile properties. Cardiac troponin C (TnC), the key regulator of cardiac muscle contraction, possesses different functional and Ca2+-binding properties compared with skeletal TnC and features a Ca2+-binding site I, which is naturally inactive. The structure of cardiac TnC in the Ca2+-saturated state has been determined by nuclear magnetic resonance spectroscopy. The regulatory domain exists in a "closed" conformation even in the Ca2+-bound (the "on") state, in contrast to all predicted models and differing significantly from the calcium-induced structure observed in skeletal TnC. This structure in the Ca2+-bound state, and its subsequent interaction with troponin I (TnI), are crucial in determining the specific regulatory mechanism for cardiac muscle contraction. Further, it will allow for an understanding of the action of calcium-sensitizing drugs, which bind to cardiac TnC and are known to enhance the ability of cardiac TnC to activate cardiac muscle contraction.
About this Structure
2CTN is a Single protein structure of sequence from Gallus gallus with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain., Sia SK, Li MX, Spyracopoulos L, Gagne SM, Liu W, Putkey JA, Sykes BD, J Biol Chem. 1997 Jul 18;272(29):18216-21. PMID:9218458
Page seeded by OCA on Thu Feb 21 16:52:28 2008
Categories: Gallus gallus | Single protein | Gagne, S M. | Li, M X. | Liu, W. | Putkey, J A. | Sia, S K. | Spyracopoulos, L. | Sykes, B D. | CA | Calcium-binding protein | Cardiac | Muscle | Regulatory
