3iuc

(Difference between revisions)

Revision as of 00:53, 25 March 2013

[GRP78_HUMAN] Note=Autoantigen in rheumatoid arthritis.^[1]

[GRP78_HUMAN] Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.^[2]

3iuc is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Wisniewska M, Karlberg T, Lehtio L, Johansson I, Kotenyova T, Moche M, Schuler H. Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78. PLoS One. 2010 Jan 11;5(1):e8625. PMID:20072699 doi:10.1371/journal.pone.0008625

↑ Corrigall VM, Bodman-Smith MD, Fife MS, Canas B, Myers LK, Wooley P, Soh C, Staines NA, Pappin DJ, Berlo SE, van Eden W, van Der Zee R, Lanchbury JS, Panayi GS. The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis. J Immunol. 2001 Feb 1;166(3):1492-8. PMID:11160188
↑ Dana RC, Welch WJ, Deftos LJ. Heat shock proteins bind calcitonin. Endocrinology. 1990 Jan;126(1):672-4. PMID:2294010

@@ Line 1: / Line 1: @@
-[[Image:3iuc.png|left|200px]]
 {{STRUCTURE_3iuc|  PDB=3iuc  |  SCENE=  }}
 ===Crystal structure of the human 70kDa heat shock protein 5 (BiP/GRP78) ATPase domain in complex with ADP===
+{{ABSTRACT_PUBMED_20072699}}
-{{ABSTRACT_PUBMED_20072699}}
+==Disease==
+[[http://www.uniprot.org/uniprot/GRP78_HUMAN GRP78_HUMAN]] Note=Autoantigen in rheumatoid arthritis.<ref>PMID:11160188</ref>
+==Function==
+[[http://www.uniprot.org/uniprot/GRP78_HUMAN GRP78_HUMAN]] Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.<ref>PMID:2294010</ref>
 ==About this Structure==
@@ Line 14: / Line 16: @@
 ==Reference==
-<ref group="xtra">PMID:020072699</ref><references group="xtra"/>
+<ref group="xtra">PMID:020072699</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Arrowsmith, C H.]]