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1kcm
From Proteopedia
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| - | [[Image:1kcm.png|left|200px]] | ||
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{{STRUCTURE_1kcm| PDB=1kcm | SCENE= }} | {{STRUCTURE_1kcm| PDB=1kcm | SCENE= }} | ||
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===Crystal Structure of Mouse PITP Alpha Void of Bound Phospholipid at 2.0 Angstroms Resolution=== | ===Crystal Structure of Mouse PITP Alpha Void of Bound Phospholipid at 2.0 Angstroms Resolution=== | ||
| + | {{ABSTRACT_PUBMED_11980708}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/PIPNA_MOUSE PIPNA_MOUSE]] Note=Defects in Pitpna are the cause of the vibrator phenotype which is characterized by early-onset progressive action tremor, degeneration of brain stem and spinal cord neurons, and juvenile death. The mutation is due to the insertion of an intracisternal A particle retrotransposon in intron 4 which results in a 5-fold reduction in protein levels. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PIPNA_MOUSE PIPNA_MOUSE]] Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:011980708</ref><references group="xtra"/> | + | <ref group="xtra">PMID:011980708</ref><references group="xtra"/><references/> |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Agianian, B.]] | [[Category: Agianian, B.]] | ||
Revision as of 01:38, 25 March 2013
Contents |
Crystal Structure of Mouse PITP Alpha Void of Bound Phospholipid at 2.0 Angstroms Resolution
Template:ABSTRACT PUBMED 11980708
Disease
[PIPNA_MOUSE] Note=Defects in Pitpna are the cause of the vibrator phenotype which is characterized by early-onset progressive action tremor, degeneration of brain stem and spinal cord neurons, and juvenile death. The mutation is due to the insertion of an intracisternal A particle retrotransposon in intron 4 which results in a 5-fold reduction in protein levels.
Function
[PIPNA_MOUSE] Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.
About this Structure
1kcm is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Schouten A, Agianian B, Westerman J, Kroon J, Wirtz KW, Gros P. Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association. EMBO J. 2002 May 1;21(9):2117-21. PMID:11980708 doi:http://dx.doi.org/10.1093/emboj/21.9.2117
