1szx

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[[Image:1szx.png|left|200px]]
 
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{{STRUCTURE_1szx| PDB=1szx | SCENE= }}
{{STRUCTURE_1szx| PDB=1szx | SCENE= }}
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===Role Of Hydrogen Bonding In The Active Site Of Human Manganese Superoxide Dismutase===
===Role Of Hydrogen Bonding In The Active Site Of Human Manganese Superoxide Dismutase===
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{{ABSTRACT_PUBMED_15170341}}
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{{ABSTRACT_PUBMED_15170341}}
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==Disease==
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[[http://www.uniprot.org/uniprot/SODM_HUMAN SODM_HUMAN]] Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:[http://omim.org/entry/612634 612634]]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
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==Function==
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[[http://www.uniprot.org/uniprot/SODM_HUMAN SODM_HUMAN]] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.<ref>PMID:10334867</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:015170341</ref><references group="xtra"/>
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<ref group="xtra">PMID:015170341</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Superoxide dismutase]]
[[Category: Superoxide dismutase]]

Revision as of 01:45, 25 March 2013

Template:STRUCTURE 1szx

Contents

Role Of Hydrogen Bonding In The Active Site Of Human Manganese Superoxide Dismutase

Template:ABSTRACT PUBMED 15170341

Disease

[SODM_HUMAN] Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

Function

[SODM_HUMAN] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.[1]

About this Structure

1szx is a 2 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1rfw. Full crystallographic information is available from OCA.

See Also

Reference

  • Greenleaf WB, Perry JJ, Hearn AS, Cabelli DE, Lepock JR, Stroupe ME, Tainer JA, Nick HS, Silverman DN. Role of hydrogen bonding in the active site of human manganese superoxide dismutase. Biochemistry. 2004 Jun 8;43(22):7038-45. PMID:15170341 doi:10.1021/bi049888k
  1. ↑ MacMillan-Crow LA, Thompson JA. Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite. Arch Biochem Biophys. 1999 Jun 1;366(1):82-8. PMID:10334867 doi:S0003-9861(99)91202-X

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OCA

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