2gcg

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[[Image:2gcg.png|left|200px]]
 
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{{STRUCTURE_2gcg| PDB=2gcg | SCENE= }}
{{STRUCTURE_2gcg| PDB=2gcg | SCENE= }}
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===Ternary Crystal Structure of Human Glyoxylate Reductase/Hydroxypyruvate Reductase===
===Ternary Crystal Structure of Human Glyoxylate Reductase/Hydroxypyruvate Reductase===
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{{ABSTRACT_PUBMED_16756993}}
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{{ABSTRACT_PUBMED_16756993}}
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==Disease==
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[[http://www.uniprot.org/uniprot/GRHPR_HUMAN GRHPR_HUMAN]] Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:[http://omim.org/entry/260000 260000]]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.<ref>PMID:10484776</ref>
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==Function==
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[[http://www.uniprot.org/uniprot/GRHPR_HUMAN GRHPR_HUMAN]] Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:016756993</ref><references group="xtra"/>
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<ref group="xtra">PMID:016756993</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Booth, M P.S.]]
[[Category: Booth, M P.S.]]

Revision as of 01:46, 25 March 2013

Template:STRUCTURE 2gcg

Contents

Ternary Crystal Structure of Human Glyoxylate Reductase/Hydroxypyruvate Reductase

Template:ABSTRACT PUBMED 16756993

Disease

[GRHPR_HUMAN] Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.[1]

Function

[GRHPR_HUMAN] Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.

About this Structure

2gcg is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Booth MP, Conners R, Rumsby G, Brady RL. Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase. J Mol Biol. 2006 Jun 30;360(1):178-89. Epub 2006 May 22. PMID:16756993 doi:10.1016/j.jmb.2006.05.018
  1. ↑ Cramer SD, Ferree PM, Lin K, Milliner DS, Holmes RP. The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II. Hum Mol Genet. 1999 Oct;8(11):2063-9. PMID:10484776

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