2ofs
From Proteopedia
m (Protected "2ofs" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2ofs.png|left|200px]] | ||
| - | |||
{{STRUCTURE_2ofs| PDB=2ofs | SCENE= }} | {{STRUCTURE_2ofs| PDB=2ofs | SCENE= }} | ||
| - | |||
===Crystal structure of human CD59=== | ===Crystal structure of human CD59=== | ||
| + | {{ABSTRACT_PUBMED_17505110}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:[http://omim.org/entry/612300 612300]].<ref>PMID:1382994</ref> | ||
| + | |||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. | ||
==About this Structure== | ==About this Structure== | ||
| Line 11: | Line 13: | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:017505110</ref><references group="xtra"/> | + | <ref group="xtra">PMID:017505110</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Davies, C.]] | [[Category: Davies, C.]] | ||
[[Category: Complement inhibitor]] | [[Category: Complement inhibitor]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
Revision as of 01:55, 25 March 2013
Contents |
Crystal structure of human CD59
Template:ABSTRACT PUBMED 17505110
Disease
[CD59_HUMAN] Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:612300].[1]
Function
[CD59_HUMAN] Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
About this Structure
2ofs is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Huang Y, Fedarovich A, Tomlinson S, Davies C. Crystal structure of CD59: implications for molecular recognition of the complement proteins C8 and C9 in the membrane-attack complex. Acta Crystallogr D Biol Crystallogr. 2007 Jun;63(Pt 6):714-21. Epub 2007, May 15. PMID:17505110 doi:10.1107/S0907444907015557
- ↑ Motoyama N, Okada N, Yamashina M, Okada H. Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene. Eur J Immunol. 1992 Oct;22(10):2669-73. PMID:1382994 doi:http://dx.doi.org/10.1002/eji.1830221029
