2pm8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2pm8.png|left|200px]]
 
- 
{{STRUCTURE_2pm8| PDB=2pm8 | SCENE= }}
{{STRUCTURE_2pm8| PDB=2pm8 | SCENE= }}
- 
===Crystal structure of recombinant full length human butyrylcholinesterase===
===Crystal structure of recombinant full length human butyrylcholinesterase===
 +
{{ABSTRACT_PUBMED_17768338}}
-
{{ABSTRACT_PUBMED_17768338}}
+
==Disease==
 +
[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
 +
 
 +
==Function==
 +
[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref><ref>PMID:19452557</ref>
==About this Structure==
==About this Structure==
Line 14: Line 16:
==Reference==
==Reference==
-
<ref group="xtra">PMID:017768338</ref><references group="xtra"/>
+
<ref group="xtra">PMID:017768338</ref><references group="xtra"/><references/>
[[Category: Cholinesterase]]
[[Category: Cholinesterase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]

Revision as of 02:00, 25 March 2013

Template:STRUCTURE 2pm8

Contents

Crystal structure of recombinant full length human butyrylcholinesterase

Template:ABSTRACT PUBMED 17768338

Disease

[CHLE_HUMAN] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.

Function

[CHLE_HUMAN] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.[1][2]

About this Structure

2pm8 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Ngamelue MN, Homma K, Lockridge O, Asojo OA. Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Sep 1;63(Pt, 9):723-7. Epub 2007 Aug 10. PMID:17768338 doi:10.1107/S1744309107037335
  1. ↑ Chilukuri N, Duysen EG, Parikh K, diTargiani R, Doctor BP, Lockridge O, Saxena A. Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents. Mol Pharmacol. 2009 Sep;76(3):612-7. doi: 10.1124/mol.109.055665. Epub 2009 Jun, 19. PMID:19542320 doi:10.1124/mol.109.055665
  2. ↑ Amitay M, Shurki A. The structure of G117H mutant of butyrylcholinesterase: nerve agents scavenger. Proteins. 2009 Nov 1;77(2):370-7. doi: 10.1002/prot.22442. PMID:19452557 doi:10.1002/prot.22442

Proteopedia Page Contributors and Editors (what is this?)

OCA, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/2pm8"
Personal tools