1mfg
From Proteopedia
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{{STRUCTURE_1mfg| PDB=1mfg | SCENE= }} | {{STRUCTURE_1mfg| PDB=1mfg | SCENE= }} | ||
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===The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor=== | ===The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor=== | ||
| + | {{ABSTRACT_PUBMED_12444095}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/LAP2_HUMAN LAP2_HUMAN]] Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state.<ref>PMID:10878805</ref> | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:012444095</ref><references group="xtra"/> | + | <ref group="xtra">PMID:012444095</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Birrane, G.]] | [[Category: Birrane, G.]] | ||
Revision as of 02:13, 25 March 2013
Contents |
The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor
Template:ABSTRACT PUBMED 12444095
Function
[LAP2_HUMAN] Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state.[1]
About this Structure
1mfg is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Birrane G, Chung J, Ladias JA. Novel mode of ligand recognition by the Erbin PDZ domain. J Biol Chem. 2003 Jan 17;278(3):1399-402. Epub 2002 Nov 19. PMID:12444095 doi:http://dx.doi.org/10.1074/jbc.C200571200
- ↑ Borg JP, Marchetto S, Le Bivic A, Ollendorff V, Jaulin-Bastard F, Saito H, Fournier E, Adelaide J, Margolis B, Birnbaum D. ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. Nat Cell Biol. 2000 Jul;2(7):407-14. PMID:10878805 doi:10.1038/35017038
