3c6m

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[[Image:3c6m.png|left|200px]]
 
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{{STRUCTURE_3c6m| PDB=3c6m | SCENE= }}
{{STRUCTURE_3c6m| PDB=3c6m | SCENE= }}
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===Crystal structure of human spermine synthase in complex with spermine and 5-methylthioadenosine===
===Crystal structure of human spermine synthase in complex with spermine and 5-methylthioadenosine===
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{{ABSTRACT_PUBMED_18367445}}
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{{ABSTRACT_PUBMED_18367445}}
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==Disease==
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[[http://www.uniprot.org/uniprot/SPSY_HUMAN SPSY_HUMAN]] Defects in SMS are the cause of X-linked syndromic mental retardation Snyder-Robinson type (MRXSSR) [MIM:[http://omim.org/entry/309583 309583]]. Characterized by moderate intellectual deficit, hypotonia, an unsteady gait, osteoporosis, kyphoscoliosis and facial asymmetry. Transmission is X-linked recessive.<ref>PMID:14508504</ref>
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==Function==
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[[http://www.uniprot.org/uniprot/SPSY_HUMAN SPSY_HUMAN]] Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:018367445</ref><references group="xtra"/>
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<ref group="xtra">PMID:018367445</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Spermine synthase]]
[[Category: Spermine synthase]]

Revision as of 02:39, 25 March 2013

Template:STRUCTURE 3c6m

Contents

Crystal structure of human spermine synthase in complex with spermine and 5-methylthioadenosine

Template:ABSTRACT PUBMED 18367445

Disease

[SPSY_HUMAN] Defects in SMS are the cause of X-linked syndromic mental retardation Snyder-Robinson type (MRXSSR) [MIM:309583]. Characterized by moderate intellectual deficit, hypotonia, an unsteady gait, osteoporosis, kyphoscoliosis and facial asymmetry. Transmission is X-linked recessive.[1]

Function

[SPSY_HUMAN] Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).

About this Structure

3c6m is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Wu H, Min J, Zeng H, McCloskey DE, Ikeguchi Y, Loppnau P, Michael AJ, Pegg AE, Plotnikov AN. Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J Biol Chem. 2008 Jun 6;283(23):16135-46. Epub 2008 Mar 26. PMID:18367445 doi:http://dx.doi.org/10.1074/jbc.M710323200
  1. ↑ Cason AL, Ikeguchi Y, Skinner C, Wood TC, Holden KR, Lubs HA, Martinez F, Simensen RJ, Stevenson RE, Pegg AE, Schwartz CE. X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome. Eur J Hum Genet. 2003 Dec;11(12):937-44. PMID:14508504 doi:10.1038/sj.ejhg.5201072

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