1qqw

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[[Image:1qqw.png|left|200px]]
 
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{{STRUCTURE_1qqw| PDB=1qqw | SCENE= }}
{{STRUCTURE_1qqw| PDB=1qqw | SCENE= }}
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===CRYSTAL STRUCTURE OF HUMAN ERYTHROCYTE CATALASE===
===CRYSTAL STRUCTURE OF HUMAN ERYTHROCYTE CATALASE===
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{{ABSTRACT_PUBMED_10666617}}
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{{ABSTRACT_PUBMED_10666617}}
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==Disease==
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[[http://www.uniprot.org/uniprot/CATA_HUMAN CATA_HUMAN]] Defects in CAT are the cause of acatalasemia (ACATLAS) [MIM:[http://omim.org/entry/614097 614097]]. A metabolic disorder characterized by absence of catalase activity in red cells and is often associated with ulcerating oral lesions.<ref>PMID:2308162</ref>
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==Function==
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[[http://www.uniprot.org/uniprot/CATA_HUMAN CATA_HUMAN]] Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.<ref>PMID:7882369</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:010666617</ref><references group="xtra"/>
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<ref group="xtra">PMID:010666617</ref><references group="xtra"/><references/>
[[Category: Catalase]]
[[Category: Catalase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]

Revision as of 02:45, 25 March 2013

Template:STRUCTURE 1qqw

Contents

CRYSTAL STRUCTURE OF HUMAN ERYTHROCYTE CATALASE

Template:ABSTRACT PUBMED 10666617

Disease

[CATA_HUMAN] Defects in CAT are the cause of acatalasemia (ACATLAS) [MIM:614097]. A metabolic disorder characterized by absence of catalase activity in red cells and is often associated with ulcerating oral lesions.[1]

Function

[CATA_HUMAN] Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.[2]

About this Structure

1qqw is a 4 chain structure with sequence from Homo sapiens. The September 2004 RCSB PDB Molecule of the Month feature on Catalase by David S. Goodsell is 10.2210/rcsb_pdb/mom_2004_9. Full crystallographic information is available from OCA.

See Also

Reference

  • Ko TP, Safo MK, Musayev FN, Di Salvo ML, Wang C, Wu SH, Abraham DJ. Structure of human erythrocyte catalase. Acta Crystallogr D Biol Crystallogr. 2000 Feb;56(Pt 2):241-5. PMID:10666617
  1. ↑ Wen JK, Osumi T, Hashimoto T, Ogata M. Molecular analysis of human acatalasemia. Identification of a splicing mutation. J Mol Biol. 1990 Jan 20;211(2):383-93. PMID:2308162 doi:http://dx.doi.org/10.1016/0022-2836(90)90359-T
  2. ↑ Takeuchi A, Miyamoto T, Yamaji K, Masuho Y, Hayashi M, Hayashi H, Onozaki K. A human erythrocyte-derived growth-promoting factor with a wide target cell spectrum: identification as catalase. Cancer Res. 1995 Apr 1;55(7):1586-9. PMID:7882369

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