3d3w
From Proteopedia
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{{STRUCTURE_3d3w| PDB=3d3w | SCENE= }} | {{STRUCTURE_3d3w| PDB=3d3w | SCENE= }} | ||
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===Structure of L-Xylulose Reductase with bound coenzyme, phosphate and hydroxide.=== | ===Structure of L-Xylulose Reductase with bound coenzyme, phosphate and hydroxide.=== | ||
| + | {{ABSTRACT_PUBMED_19337691}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/DCXR_HUMAN DCXR_HUMAN]] Note=The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/DCXR_HUMAN DCXR_HUMAN]] Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:019337691</ref><references group="xtra"/> | + | <ref group="xtra">PMID:019337691</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: L-xylulose reductase]] | [[Category: L-xylulose reductase]] | ||
Revision as of 02:56, 25 March 2013
Contents |
Structure of L-Xylulose Reductase with bound coenzyme, phosphate and hydroxide.
Template:ABSTRACT PUBMED 19337691
Disease
[DCXR_HUMAN] Note=The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose.
Function
[DCXR_HUMAN] Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
About this Structure
3d3w is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zhao HT, Endo S, Ishikura S, Chung R, Hogg PJ, Hara A, El-Kabbani O. Structure/function analysis of a critical disulfide bond in the active site of L: -xylulose reductase. Cell Mol Life Sci. 2009 Apr 2. PMID:19337691 doi:10.1007/s00018-009-9065-y
