3n1f
From Proteopedia
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
| - | [[Image:3n1f.png|left|200px]] | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_3n1f", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_3n1f| PDB=3n1f | SCENE= }} | {{STRUCTURE_3n1f| PDB=3n1f | SCENE= }} | ||
| - | |||
===Crystal Structure of IhhN bound to CDOFn3=== | ===Crystal Structure of IhhN bound to CDOFn3=== | ||
| - | |||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_20519495}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 20519495 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_20519495}} | {{ABSTRACT_PUBMED_20519495}} | ||
==Disease== | ==Disease== | ||
| - | + | [[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Defects in CDON are the cause of holoprosencephaly type 11 (HPE11) [MIM:[http://omim.org/entry/614226 614226]]. HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. | |
| + | |||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3n1f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1F OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020519495</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Kavran, J M.]] | [[Category: Kavran, J M.]] | ||
[[Category: Leahy, D J.]] | [[Category: Leahy, D J.]] | ||
[[Category: Binding site]] | [[Category: Binding site]] | ||
| - | [[Category: Calcium]] | ||
[[Category: Cell adhesion molecule]] | [[Category: Cell adhesion molecule]] | ||
[[Category: Cell cycle protein]] | [[Category: Cell cycle protein]] | ||
| Line 48: | Line 34: | ||
[[Category: Tertiary]] | [[Category: Tertiary]] | ||
[[Category: Tumor suppressor protein]] | [[Category: Tumor suppressor protein]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:13:03 2010'' | ||
Revision as of 03:03, 25 March 2013
Contents |
Crystal Structure of IhhN bound to CDOFn3
Template:ABSTRACT PUBMED 20519495
Disease
[CDON_HUMAN] Defects in CDON are the cause of holoprosencephaly type 11 (HPE11) [MIM:614226]. HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.
Function
[CDON_HUMAN] Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).
About this Structure
3n1f is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kavran JM, Ward MD, Oladosu OO, Mulepati S, Leahy DJ. All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. J Biol Chem. 2010 Aug 6;285(32):24584-90. Epub 2010 Jun 1. PMID:20519495 doi:10.1074/jbc.M110.131680
Categories: Homo sapiens | Kavran, J M. | Leahy, D J. | Binding site | Cell adhesion molecule | Cell cycle protein | Cell line | Cell surface | Conserved sequence | Fibronectin | Hedgehog protein | Immunoglobulin g | Membrane glycoprotein | Membrane protein | Protein binding | Receptor | Sequence homology | Signal transduction | Tertiary | Tumor suppressor protein
