3n1f

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Revision as of 03:03, 25 March 2013

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Template:STRUCTURE 3n1f

Contents 1 Crystal Structure of IhhN bound to CDOFn3 2 Disease 3 Function 4 About this Structure 5 Reference

Crystal Structure of IhhN bound to CDOFn3

Template:ABSTRACT PUBMED 20519495

Disease

[CDON_HUMAN] Defects in CDON are the cause of holoprosencephaly type 11 (HPE11) [MIM:614226]. HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.

Function

[CDON_HUMAN] Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

About this Structure

3n1f is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Kavran JM, Ward MD, Oladosu OO, Mulepati S, Leahy DJ. All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. J Biol Chem. 2010 Aug 6;285(32):24584-90. Epub 2010 Jun 1. PMID:20519495 doi:10.1074/jbc.M110.131680