1pdg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1pdg" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:1pdg.png|left|200px]]
 
- 
{{STRUCTURE_1pdg| PDB=1pdg | SCENE= }}
{{STRUCTURE_1pdg| PDB=1pdg | SCENE= }}
- 
===CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB===
===CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB===
 +
{{ABSTRACT_PUBMED_1396586}}
-
{{ABSTRACT_PUBMED_1396586}}
+
==Disease==
 +
[[http://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN]] Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.<ref>PMID:12660034</ref>
 +
 
 +
==Function==
 +
[[http://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN]] Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).
==About this Structure==
==About this Structure==
Line 11: Line 13:
==Reference==
==Reference==
-
<ref group="xtra">PMID:001396586</ref><references group="xtra"/>
+
<ref group="xtra">PMID:001396586</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Darcy, A D.]]
[[Category: Darcy, A D.]]

Revision as of 03:17, 25 March 2013

Template:STRUCTURE 1pdg

Contents

CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB

Template:ABSTRACT PUBMED 1396586

Disease

[PDGFB_HUMAN] Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.[1]

Function

[PDGFB_HUMAN] Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).

About this Structure

1pdg is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Oefner C, D'Arcy A, Winkler FK, Eggimann B, Hosang M. Crystal structure of human platelet-derived growth factor BB. EMBO J. 1992 Nov;11(11):3921-6. PMID:1396586
  1. ↑ Sandberg AA, Anderson WD, Fredenberg C, Hashimoto H. Dermatofibrosarcoma protuberans of breast. Cancer Genet Cytogenet. 2003 Apr 1;142(1):56-9. PMID:12660034

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pdg"
Personal tools