3l0k
From Proteopedia
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{{STRUCTURE_3l0k| PDB=3l0k | SCENE= }} | {{STRUCTURE_3l0k| PDB=3l0k | SCENE= }} | ||
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===Human orotidyl-5'-monophosphate decarboxylase in complex with 6-acetyl-UMP=== | ===Human orotidyl-5'-monophosphate decarboxylase in complex with 6-acetyl-UMP=== | ||
| + | {{ABSTRACT_PUBMED_19472232}} | ||
| - | + | ==Disease== | |
| - | + | [[http://www.uniprot.org/uniprot/PYR5_HUMAN PYR5_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3l0k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ex0 3ex0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L0K OCA]. | |
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| + | ==See Also== | ||
| + | *[[Phosphoribosyltransferase|Phosphoribosyltransferase]] | ||
| + | *[[Uridine 5'-monophosphate synthase|Uridine 5'-monophosphate synthase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019472232</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Orotidine-5'-phosphate decarboxylase]] | [[Category: Orotidine-5'-phosphate decarboxylase]] | ||
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[[Category: Rudolph, M.]] | [[Category: Rudolph, M.]] | ||
[[Category: Decarboxylase]] | [[Category: Decarboxylase]] | ||
| + | [[Category: Lyase]] | ||
[[Category: Multifunctional enzyme]] | [[Category: Multifunctional enzyme]] | ||
[[Category: Pyrimidine biosynthesis]] | [[Category: Pyrimidine biosynthesis]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 19:28:23 2010'' | ||
Revision as of 03:21, 25 March 2013
Contents |
Human orotidyl-5'-monophosphate decarboxylase in complex with 6-acetyl-UMP
Template:ABSTRACT PUBMED 19472232
Disease
[PYR5_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.[1]
About this Structure
3l0k is a 2 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 3ex0. Full crystallographic information is available from OCA.
See Also
Reference
- Heinrich D, Diederichsen U, Rudolph MG. Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase. Chemistry. 2009 Jul 6;15(27):6619-25. PMID:19472232 doi:10.1002/chem.200900397
