1v7n
From Proteopedia
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{{STRUCTURE_1v7n| PDB=1v7n | SCENE= }} | {{STRUCTURE_1v7n| PDB=1v7n | SCENE= }} | ||
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===Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab=== | ===Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab=== | ||
| + | {{ABSTRACT_PUBMED_14769915}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/TPO_HUMAN TPO_HUMAN]] Defects in THPO are the cause of thrombocythemia type 1 (THCYT1) [MIM:[http://omim.org/entry/187950 187950]]. A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.<ref>PMID:9425899</ref> | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/TPO_HUMAN TPO_HUMAN]] Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:014769915</ref><ref group="xtra">PMID:011976502</ref><references group="xtra"/> | + | <ref group="xtra">PMID:014769915</ref><ref group="xtra">PMID:011976502</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
Revision as of 03:29, 25 March 2013
Contents |
Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab
Template:ABSTRACT PUBMED 14769915
Disease
[TPO_HUMAN] Defects in THPO are the cause of thrombocythemia type 1 (THCYT1) [MIM:187950]. A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.[1]
Function
[TPO_HUMAN] Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
About this Structure
1v7n is a 12 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
See Also
Reference
- Feese MD, Tamada T, Kato Y, Maeda Y, Hirose M, Matsukura Y, Shigematsu H, Muto T, Matsumoto A, Watarai H, Ogami K, Tahara T, Kato T, Miyazaki H, Kuroki R. Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1816-21. Epub 2004 Feb 9. PMID:14769915 doi:http://dx.doi.org/10.1073/pnas.0308530100
- Kuroki R, Hirose M, Kato Y, Feese MD, Tamada T, Shigematsu H, Watarai H, Maeda Y, Tahara T, Kato T, Miyazaki H. Crystallization of the functional domain of human thrombopoietin using an antigen-binding fragment derived from neutralizing monoclonal antibody. Acta Crystallogr D Biol Crystallogr. 2002 May;58(Pt 5):856-8. Epub 2002, Apr 26. PMID:11976502
- ↑ Wiestner A, Schlemper RJ, van der Maas AP, Skoda RC. An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia. Nat Genet. 1998 Jan;18(1):49-52. PMID:9425899 doi:10.1038/ng0198-49
