3agv
From Proteopedia
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{{STRUCTURE_3agv| PDB=3agv | SCENE= }} | {{STRUCTURE_3agv| PDB=3agv | SCENE= }} | ||
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===Crystal structure of a human IgG-aptamer complex=== | ===Crystal structure of a human IgG-aptamer complex=== | ||
| + | {{ABSTRACT_PUBMED_20675355}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:020675355</ref><references group="xtra"/> | + | <ref group="xtra">PMID:020675355</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Adachi, H.]] | [[Category: Adachi, H.]] | ||
Revision as of 03:37, 25 March 2013
Contents |
Crystal structure of a human IgG-aptamer complex
Template:ABSTRACT PUBMED 20675355
Disease
[IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
About this Structure
3agv is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Nomura Y, Sugiyama S, Sakamoto T, Miyakawa S, Adachi H, Takano K, Murakami S, Inoue T, Mori Y, Nakamura Y, Matsumura H. Conformational plasticity of RNA for target recognition as revealed by the 2.15 A crystal structure of a human IgG-aptamer complex. Nucleic Acids Res. 2010 Jul 30. PMID:20675355 doi:10.1093/nar/gkq615
