3p5o

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[[Image:3p5o.png|left|200px]]
 
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{{STRUCTURE_3p5o| PDB=3p5o | SCENE= }}
{{STRUCTURE_3p5o| PDB=3p5o | SCENE= }}
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===Crystal Structure of the First Bromodomain of Human Brd4 in complex with IBET inhibitor===
===Crystal Structure of the First Bromodomain of Human Brd4 in complex with IBET inhibitor===
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{{ABSTRACT_PUBMED_21068722}}
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==Disease==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref><ref>PMID:11733348</ref>
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==Function==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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(as it appears on PubMed at http://www.pubmed.gov), where 21068722 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21068722}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:21068722</ref><references group="xtra"/>
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<ref group="xtra">PMID:021068722</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chung, C.]]
[[Category: Chung, C.]]

Revision as of 03:55, 25 March 2013

Template:STRUCTURE 3p5o

Contents

Crystal Structure of the First Bromodomain of Human Brd4 in complex with IBET inhibitor

Template:ABSTRACT PUBMED 21068722

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1][2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

3p5o is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Nicodeme E, Jeffrey KL, Schaefer U, Beinke S, Dewell S, Chung CW, Chandwani R, Marazzi I, Wilson P, Coste H, White J, Kirilovsky J, Rice CM, Lora JM, Prinjha RK, Lee K, Tarakhovsky A. Suppression of inflammation by a synthetic histone mimic. Nature. 2010 Dec 23;468(7327):1119-23. Epub 2010 Nov 10. PMID:21068722 doi:10.1038/nature09589
  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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OCA

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