2uyz

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[[Image:2uyz.png|left|200px]]
 
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{{STRUCTURE_2uyz| PDB=2uyz | SCENE= }}
{{STRUCTURE_2uyz| PDB=2uyz | SCENE= }}
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===NON-COVALENT COMPLEX BETWEEN UBC9 AND SUMO1===
===NON-COVALENT COMPLEX BETWEEN UBC9 AND SUMO1===
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{{ABSTRACT_PUBMED_17491593}}
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{{ABSTRACT_PUBMED_17491593}}
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==Function==
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[[http://www.uniprot.org/uniprot/UBC9_MOUSE UBC9_MOUSE]] Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture, chromosome segregation and embryonic viability. Necessary for sumoylation of FOXL2 and KAT5 (By similarity).<ref>PMID:16326389</ref><ref>PMID:17187077</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:017491593</ref><references group="xtra"/>
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<ref group="xtra">PMID:017491593</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]

Revision as of 04:28, 25 March 2013

Template:STRUCTURE 2uyz

Contents

NON-COVALENT COMPLEX BETWEEN UBC9 AND SUMO1

Template:ABSTRACT PUBMED 17491593

Function

[UBC9_MOUSE] Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture, chromosome segregation and embryonic viability. Necessary for sumoylation of FOXL2 and KAT5 (By similarity).[1][2]

About this Structure

2uyz is a 2 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

See Also

Reference

  • Knipscheer P, van Dijk WJ, Olsen JV, Mann M, Sixma TK. Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation. EMBO J. 2007 Jun 6;26(11):2797-807. Epub 2007 May 10. PMID:17491593
  1. ↑ Nacerddine K, Lehembre F, Bhaumik M, Artus J, Cohen-Tannoudji M, Babinet C, Pandolfi PP, Dejean A. The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice. Dev Cell. 2005 Dec;9(6):769-79. PMID:16326389 doi:S1534-5807(05)00389-8
  2. ↑ Park SW, Hu X, Gupta P, Lin YP, Ha SG, Wei LN. SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells. Nat Struct Mol Biol. 2007 Jan;14(1):68-75. Epub 2006 Dec 24. PMID:17187077 doi:10.1038/nsmb1185

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