3lri

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[[Image:3lri.png|left|200px]]
 
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{{STRUCTURE_3lri| PDB=3lri | SCENE= }}
{{STRUCTURE_3lri| PDB=3lri | SCENE= }}
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===Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I===
===Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I===
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{{ABSTRACT_PUBMED_10744677}}
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{{ABSTRACT_PUBMED_10744677}}
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==Disease==
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[[http://www.uniprot.org/uniprot/IGF1B_HUMAN IGF1B_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
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==Function==
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[[http://www.uniprot.org/uniprot/IGF1B_HUMAN IGF1B_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:010744677</ref><references group="xtra"/>
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<ref group="xtra">PMID:010744677</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Carver, J A.]]
[[Category: Carver, J A.]]

Revision as of 04:33, 25 March 2013

Template:STRUCTURE 3lri

Contents

Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I

Template:ABSTRACT PUBMED 10744677

Disease

[IGF1B_HUMAN] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.

Function

[IGF1B_HUMAN] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.[1]

About this Structure

3lri is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

See Also

Reference

  • Laajoki LG, Francis GL, Wallace JC, Carver JA, Keniry MA. Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I. J Biol Chem. 2000 Apr 7;275(14):10009-15. PMID:10744677
  1. ↑ Zoidis E, Ghirlanda-Keller C, Schmid C. Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I. Mol Cell Biochem. 2011 Feb;348(1-2):33-42. doi: 10.1007/s11010-010-0634-z. Epub, 2010 Nov 13. PMID:21076856 doi:10.1007/s11010-010-0634-z

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