2pno

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[[Image:2pno.png|left|200px]]
 
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{{STRUCTURE_2pno| PDB=2pno | SCENE= }}
{{STRUCTURE_2pno| PDB=2pno | SCENE= }}
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===Crystal structure of human leukotriene C4 synthase===
===Crystal structure of human leukotriene C4 synthase===
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{{ABSTRACT_PUBMED_17632548}}
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{{ABSTRACT_PUBMED_17632548}}
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==Disease==
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[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
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==Function==
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[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:017632548</ref><references group="xtra"/>
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<ref group="xtra">PMID:017632548</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ago, H.]]
[[Category: Ago, H.]]

Revision as of 04:40, 25 March 2013

Template:STRUCTURE 2pno

Contents

Crystal structure of human leukotriene C4 synthase

Template:ABSTRACT PUBMED 17632548

Disease

[LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.

Function

[LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.

About this Structure

2pno is a 12 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Ago H, Kanaoka Y, Irikura D, Lam BK, Shimamura T, Austen KF, Miyano M. Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature. 2007 Aug 2;448(7153):609-12. Epub 2007 Jul 15. PMID:17632548 doi:10.1038/nature05936

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OCA

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