1wm0

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[[Image:1wm0.png|left|200px]]
 
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{{STRUCTURE_1wm0| PDB=1wm0 | SCENE= }}
{{STRUCTURE_1wm0| PDB=1wm0 | SCENE= }}
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===PPARgamma in complex with a 2-BABA compound===
===PPARgamma in complex with a 2-BABA compound===
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{{ABSTRACT_PUBMED_15258145}}
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{{ABSTRACT_PUBMED_15258145}}
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==Function==
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[[http://www.uniprot.org/uniprot/NCOA2_MOUSE NCOA2_MOUSE]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:12507421</ref><ref>PMID:11997499</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:015258145</ref><references group="xtra"/>
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<ref group="xtra">PMID:015258145</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Gustavsson, A L.]]
[[Category: Gustavsson, A L.]]

Revision as of 04:40, 25 March 2013

Template:STRUCTURE 1wm0

Contents

PPARgamma in complex with a 2-BABA compound

Template:ABSTRACT PUBMED 15258145

Function

[NCOA2_MOUSE] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.[1][2]

About this Structure

1wm0 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Ostberg T, Svensson S, Selen G, Uppenberg J, Thor M, Sundbom M, Sydow-Backman M, Gustavsson AL, Jendeberg L. A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects. J Biol Chem. 2004 Sep 24;279(39):41124-30. Epub 2004 Jul 15. PMID:15258145 doi:10.1074/jbc.M401552200
  1. ↑ Picard F, Gehin M, Annicotte J, Rocchi S, Champy MF, O'Malley BW, Chambon P, Auwerx J. SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell. 2002 Dec 27;111(7):931-41. PMID:12507421
  2. ↑ Lee YH, Koh SS, Zhang X, Cheng X, Stallcup MR. Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities. Mol Cell Biol. 2002 Jun;22(11):3621-32. PMID:11997499

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