1a1x
From Proteopedia
(Difference between revisions)
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| - | [[Image:1a1x.png|left|200px]] | ||
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{{STRUCTURE_1a1x| PDB=1a1x | SCENE= }} | {{STRUCTURE_1a1x| PDB=1a1x | SCENE= }} | ||
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===CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES=== | ===CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES=== | ||
| + | {{ABSTRACT_PUBMED_9520380}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref> | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:009520380</ref><ref group="xtra">PMID:019113835</ref><references group="xtra"/> | + | <ref group="xtra">PMID:009520380</ref><ref group="xtra">PMID:019113835</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Croce, C M.]] | [[Category: Croce, C M.]] | ||
Revision as of 05:21, 25 March 2013
Contents |
CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES
Template:ABSTRACT PUBMED 9520380
Disease
[MTCP1_HUMAN] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.
Function
[MTCP1_HUMAN] Enhances the phosphorylation and activation of AKT1 and AKT2.[1]
About this Structure
1a1x is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Fu ZQ, Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Rothstein JL, Croce CM, Weber IT, Harrison RW. Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3413-8. PMID:9520380
- Liang S, Li L, Hsu WL, Pilcher MN, Uversky V, Zhou Y, Dunker AK, Meroueh SO. Exploring the molecular design of protein interaction sites with molecular dynamics simulations and free energy calculations. Biochemistry. 2009 Jan 20;48(2):399-414. PMID:19113835 doi:10.1021/bi8017043
