This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2bdi

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2bdi" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:2bdi.png|left|200px]]
 
- 
{{STRUCTURE_2bdi| PDB=2bdi | SCENE= }}
{{STRUCTURE_2bdi| PDB=2bdi | SCENE= }}
- 
===Human Kallikrein 4 complex with cobalt and p-aminobenzamidine===
===Human Kallikrein 4 complex with cobalt and p-aminobenzamidine===
 +
{{ABSTRACT_PUBMED_16950394}}
-
{{ABSTRACT_PUBMED_16950394}}
+
==Disease==
 +
[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[http://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>
 +
 
 +
==Function==
 +
[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref>
==About this Structure==
==About this Structure==
Line 11: Line 13:
==Reference==
==Reference==
-
<ref group="xtra">PMID:016950394</ref><references group="xtra"/>
+
<ref group="xtra">PMID:016950394</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bode, W.]]
[[Category: Bode, W.]]

Revision as of 05:35, 25 March 2013

Template:STRUCTURE 2bdi

Contents

Human Kallikrein 4 complex with cobalt and p-aminobenzamidine

Template:ABSTRACT PUBMED 16950394

Disease

[KLK4_HUMAN] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:204700]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.[1]

Function

[KLK4_HUMAN] Involved in enamel formation.[2]

About this Structure

2bdi is a 16 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Debela M, Magdolen V, Grimminger V, Sommerhoff C, Messerschmidt A, Huber R, Friedrich R, Bode W, Goettig P. Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site. J Mol Biol. 2006 Oct 6;362(5):1094-107. Epub 2006 Aug 3. PMID:16950394 doi:10.1016/j.jmb.2006.08.003
  1. ↑ Hart PS, Hart TC, Michalec MD, Ryu OH, Simmons D, Hong S, Wright JT. Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta. J Med Genet. 2004 Jul;41(7):545-9. PMID:15235027
  2. ↑ Hart PS, Hart TC, Michalec MD, Ryu OH, Simmons D, Hong S, Wright JT. Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta. J Med Genet. 2004 Jul;41(7):545-9. PMID:15235027

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bdi"
Personal tools