3nps

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[[Image:3nps.png|left|200px]]
 
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{{STRUCTURE_3nps| PDB=3nps | SCENE= }}
{{STRUCTURE_3nps| PDB=3nps | SCENE= }}
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===Crystal structure of membrane-type serine protease 1 (MT-SP1) in complex with the Fab Inhibitor S4===
===Crystal structure of membrane-type serine protease 1 (MT-SP1) in complex with the Fab Inhibitor S4===
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{{ABSTRACT_PUBMED_22154938}}
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==Disease==
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[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[http://omim.org/entry/610765 610765]]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref>
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==Function==
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[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
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(as it appears on PubMed at http://www.pubmed.gov), where 22154938 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22154938}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:022154938</ref><references group="xtra"/>
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<ref group="xtra">PMID:022154938</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Matriptase]]
[[Category: Matriptase]]

Revision as of 05:50, 25 March 2013

Template:STRUCTURE 3nps

Contents

Crystal structure of membrane-type serine protease 1 (MT-SP1) in complex with the Fab Inhibitor S4

Template:ABSTRACT PUBMED 22154938

Disease

[ST14_HUMAN] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.[1]

Function

[ST14_HUMAN] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.

About this Structure

3nps is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Schneider EL, Lee MS, Baharuddin A, Goetz DH, Farady CJ, Ward M, Wang CI, Craik CS. A reverse binding motif that contributes to specific protease inhibition by antibodies. J Mol Biol. 2012 Jan 27;415(4):699-715. Epub 2011 Nov 27. PMID:22154938 doi:10.1016/j.jmb.2011.11.036
  1. ↑ Basel-Vanagaite L, Attia R, Ishida-Yamamoto A, Rainshtein L, Ben Amitai D, Lurie R, Pasmanik-Chor M, Indelman M, Zvulunov A, Saban S, Magal N, Sprecher E, Shohat M. Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase. Am J Hum Genet. 2007 Mar;80(3):467-77. Epub 2007 Jan 23. PMID:17273967 doi:S0002-9297(07)60095-0

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OCA

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