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1qvn
From Proteopedia
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| - | [[Image:1qvn.png|left|200px]] | ||
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{{STRUCTURE_1qvn| PDB=1qvn | SCENE= }} | {{STRUCTURE_1qvn| PDB=1qvn | SCENE= }} | ||
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===Structure of SP4160 Bound to IL-2 V69A=== | ===Structure of SP4160 Bound to IL-2 V69A=== | ||
| + | {{ABSTRACT_PUBMED_17032757}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:017032757</ref><references group="xtra"/> | + | <ref group="xtra">PMID:017032757</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Delano, W L.]] | [[Category: Delano, W L.]] | ||
Revision as of 05:56, 25 March 2013
Contents |
Structure of SP4160 Bound to IL-2 V69A
Template:ABSTRACT PUBMED 17032757
Disease
[IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
Function
[IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
About this Structure
1qvn is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Thanos CD, DeLano WL, Wells JA. Hot-spot mimicry of a cytokine receptor by a small molecule. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15422-7. Epub 2006 Oct 10. PMID:17032757 doi:10.1073/pnas.0607058103
