1qvn

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[[Image:1qvn.png|left|200px]]
 
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{{STRUCTURE_1qvn| PDB=1qvn | SCENE= }}
{{STRUCTURE_1qvn| PDB=1qvn | SCENE= }}
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===Structure of SP4160 Bound to IL-2 V69A===
===Structure of SP4160 Bound to IL-2 V69A===
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{{ABSTRACT_PUBMED_17032757}}
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{{ABSTRACT_PUBMED_17032757}}
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==Disease==
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
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==Function==
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:017032757</ref><references group="xtra"/>
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<ref group="xtra">PMID:017032757</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Delano, W L.]]
[[Category: Delano, W L.]]

Revision as of 05:56, 25 March 2013

Template:STRUCTURE 1qvn

Contents

Structure of SP4160 Bound to IL-2 V69A

Template:ABSTRACT PUBMED 17032757

Disease

[IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Function

[IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

About this Structure

1qvn is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Thanos CD, DeLano WL, Wells JA. Hot-spot mimicry of a cytokine receptor by a small molecule. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15422-7. Epub 2006 Oct 10. PMID:17032757 doi:10.1073/pnas.0607058103

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OCA

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